Depue & Collins's (D&C's) work relies on extrapolation from data obtained through studies in experimental animals, and needs support from studies of the role of dopamine (DA) neurotransmission in human behaviour. Here we review evidence from two sources: (1) studies of patients with Parkinson's disease and (2) positron emission tomography (PET) studies of DA neurotransmission, which we believe lend support to Depue & Collins's theory, and which can potentially form the basis for a true neurochemistry of personality.

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Introduction: the age of reflexion Part I. Romanticism: 1. Romanticism and the sciences David Knight 2. Schelling and the origins of his Naturphilosophie S. R. Morgan 3. Romantic philosophy and the organization of the disciplines: the founding of the Humboldt University of Berlin Elinor S. Shaffer 4. Historical consciousness in the German Romantic Naturforschung Dietrich Von Engelhardt 5. Theology and the sciences in the German Romantic period Frederick Gregory 6. Genius in Romantic natural philosophy Simon Shaffer Part II. Sciences of (...) the Organic: 7. Doctors contra clysters and feudalism: the consequences of a Romantic revolution Nelly Tsouyopoulos 8. Morphotypes and the historical-genetic method in Romantic biology Timothy Lenoir 9. ’Metaphorical mystifications’: the Romantic gestation of nature in British biology Evelleen Richards 10. Transcendental anatomy Philip F. Rehbock 11. Romantic thought and the origins of cell theory L. S. Jacyna 12. Alexander von Humbolt and the geography of vegetation Malcolm Nicholson Part III. Sciences of the Inorganic: 13. Goethe, colour, and the science of seeing Dennis L. Sepper 14. Johann Wilhelm Ritter: Romantic physics in Germany Walter D. Wetzels 15. The power and the glory: Humphrey Davy and Romanticism Christopher Lawrence 16. Oersted’s discovery of electromagnetism H. A. M. Snelders 17. Caves, fossils and the history of the earth Nicholas A. Rupke Part IV. Literature and the Sciences: 18. Goethe’s use of chemical theory in his Elective Affinities Jeremy Adler 19. Kleist’s bedlam: abnormal psychology and psychiatry in the works of Heinrich von Kleist Nigel Reeves 20. Coleridge and the sciences Trevor H. Levere 21. Nature’s book: the language of science in the American Renaissance David van Leer 22. The shattered whole: Georg Buchner and Naturphilosophie John Reddick. (shrink)

One way to solve the epistemic regress problem would be to show that we can acquire justification by means of an infinite regress. This is infinitism. This view has not been popular, but Peter Klein has developed a sophisticated version of infinitism according to which all justified beliefs depend upon an infinite regress of reasons. Klein's argument for infinitism is unpersuasive, but he successfully responds to the most compelling extant objections to the view. A key component of his position is (...) his claim that an infinite regress is necessary, but not sufficient, for justified belief. This enables infinitism to avoid a number of otherwise compelling objections. However, it commits infinitism to the existence of an additional feature of reasons that is necessary and, together with the regress condition, sufficient for justified belief. The trouble with infinitism is that any such condition could account for the connection between justification and truth only by undermining the rationale for the regress condition itself. (shrink)

Recent scholarship in technology and society studies has given attention to the notion of technological citizenship. This article seeks to further integrate perspectives on this topic with theoretical contributions about the development of moral autonomy. The author challenges the presumption that the strategy of expanding opportunities for participation in technological decision making will in itself develop people's autonomy and citizenship. He argues that concurrent efforts must be made to democratize the political-economic structures of key technologies and to help people prepare (...) morally for citizenship roles in governing these technologies. On this basis, a series of initiatives are suggested. (shrink)

The problem of the criterion says that we can know a proposition only if we first know a criterion of truth and vice versa, hence, we cannot know any proposition or any criterion of truth. The epistemic levels response says that since knowledge does not require knowledge about knowledge, we can know a proposition without knowing a criterion of truth. This response (advocated by Chisholm and Van Cleve) presupposes that criteria of truth are epistemic principles. In general, however, criteria of (...) truth are not epistemic principles, so the epistemic levels response to the problem of the criterion fails. (shrink)

ABSTRACTMiranda Fricker has characterized epistemic injustice as “a kind of injustice in which someone is wronged specifically in her capacity as a knower” (2007, Epistemic injustice: Power & the e...

The best extant statement of the epistemic regress problem makes assumptions that are too strong. An improved version assumes only that that reasons require support, that no proposition is supported only by endless regresses of reasons, and that some proposition is supported. These assumptions are individually plausible but jointly inconsistent. Attempts to explain support by means of unconceptualized sensations, contextually immunized propositions, endless regresses, and holistic coherence all require either additional reasons or an external condition on support that is arbitrary (...) from the believer's own point of view. (shrink)

As the title suggests, Breeur’s project is to discuss three key ideas: lies, stupidity, and imposture. The book is organized into two parts of two chapters each, followed by an appendix. The individual chapters and sub-sections are well-written and philosophically sophisticated. However, the reader will be disappointed if they expect a sustained analysis of the relations among the book’s titular ideas or a unified account of their role in the breakdown of respect for truth more broadly. Breeur’s approach is more (...) episodic, laying out valuable considerations and enticing formulations, but often breaking off before spelling out their full implications or connecting them to previous discussions in the book. His discussion clearly opens up these additional avenues of thought, but the task of going down them is left largely to the reader. This review briefly takes up each of Breeur’s themes: lies, stupidity, and imposture. (shrink)

OBJECTIVE: To apply component analysis, a structured approach to the ethical analysis of risks and potential benefits in research, to published emergency research using a waiver of/exception from informed consent. The hypothesis was that component analysis could be used with a high degree of interrater reliability, and that the vast majority of emergency research would comply with a minimal-risk threshold. METHODS: A Medline search and manual search were done to identify studies using a waiver of/exception from informed consent published between (...) July 1996 and December 2000. A review panel of physicians and bioethicists independently classified nontherapeutic procedures in each study as minimal risk, probably minimal risk, or probably more than minimal risk. RESULTS: Seventy studies using a waiver of/exception from informed consent were identified. A majority of reviewers classified nontherapeutic procedures in 62 studies (88.6%) as minimal risk. Reviewers classified nontherapeutic procedures in six studies (8.6%) as minimal risk or probably minimal risk. In two studies (2.9%), nontherapeutic procedures were classified as probably more than minimal risk. The intraclass correlation coefficient was 0.89 (95% CI = 0.85 to 0.93), indicating very high interrater reliability. CONCLUSIONS: Component analysis can be used with high reliability to review emergency research and may improve the consistency of institutional review board review of emergency research. The vast majority of published emergency research performed using a waiver of/exception from consent complies with a properly-applied minimal-risk threshold. A minimal-risk threshold for nontherapeutic procedures protects subjects better than current U.S. regulations while permitting important emergency research to continue. (shrink)

This exploratory study set out to pilot use of a Risk Innovation approach to support the development of advanced biopreservation technologies, and the societally beneficial development of advanced technologies more broadly. This is the first study to apply the Risk Innovation approach — which has previously been used to help individual organizations clarify areas of value and threats — to multiple entities involved in developing an emerging technology.

Although it has been largely neglected in contemporary philosophy , the problem of the criterion raises questions which must be addressed by any complete account of knowledge . But the problem of the criterion suffers not onl.

Paul Churchland argues that the continuity of human intellectual development provides evidence against folk psychology and traditional epistemology, since these latter find purchase only at the later stages of intellectual development. He supports this contention with an analogy from the history of thermodynamics. Careful attention to the thermodynamics analogy shows that the argument from continuity does not provide independent support for eliminative materialism. The argument also rests upon claims about continuity which do not support the claim that the continuity of (...) intellectual development is evidence for the elimination of folk psychology. Traditional epistemology and folk psychology should not yet be abandoned. (shrink)

Bonhoeffer’s New Beginning investigates Dietrich Bonhoeffer's life-affirming answer to how we begin again after devastation. Combining scholarly rigor and existential honesty, DeCort argues that Bonhoeffer offers an ethical and moral vision of radical hope vis-à-vis the perceived absence of God in the face of devastation.

BonJour has proposed background conditions on internalist justification, which Kornblith argues are inconsistent with a core internalist ‘credo’ – that subjects internally alike are justificationally alike – signaling the ‘death’ of internalism. The funeral arrangements are premature, though more systematic consideration of background conditions is needed. The majority of BonJour's conditions are not background conditions as their failure makes an epistemically relevant internal difference. This neutralizes Kornblith's criticisms and reveals how the proposed conditions are not departures from internalism. BonJour's background (...) conditions are simply conditions, the credo remains intact, and Kornblith's objections do not spell problems for internalism, let alone death. (shrink)

Theology, Fantasy, and the Imagination analyzes theological, religious, and philosophical themes in classical Christian fantasy, contemporary “post-Christian” fantasy, and fantasy at play in table top games such as Dungeons and Dragons and Magic: the Gathering.

Books reviewed:Mark BevirThe Logic of the History of Ideas.

The notion of function is indispensable to our understanding of distinctions such as that between being broken and being in working order (for artifacts) and between being diseased and being healthy (for organisms). A clear account of the ontology of functions and functioning is thus an important desideratum for any top-level ontology intended for application to domains such as engineering or medicine. The benefit of using top-level ontologies in applied ontology can only be realized when each of the categories identified (...) and defined by a top-level ontology is integrated with the others in a coherent fashion. Basic Formal Ontology (BFO) has from the beginning included function as one of its categories, exploiting a version of the etiological account of function that is framed at a level of generality sufficient to accommodate both biological and artifactual functions. This account has been subjected to a series of criticisms and refinements. We here articulate BFO’s account of function, provide some reasons for favoring it over competing views, and defend it against objections. (shrink)

This study examined linguistic patterns in mothers’ reports about their toddlers’ involvement in everyday household work, as a way to understand the parental ethnotheories that may guide children’s prosocial helping and development. Mothers from two cultural groups – US Mexican-heritage families with backgrounds in indigenous American communities and middle-class European American families – were interviewed regarding how their 2- to 3-year-old toddler gets involved in help with everyday household work. The study’s analytic focus was mothers’ responses to interview questions asking (...) about the child’s efforts to help with a variety of everyday household work tasks. Results showed that mothers responded with linguistic patterns that were indicative of ethnotheoretical assumptions regarding children’s agency and children’s prosocial intentions, with notable contrasts between the two cultural groups. Nearly all US Mexican-heritage mothers reported children’s contributions and participation using linguistic forms that centered children’s agency and prosocial initiative, which corresponds with extensive evidence suggesting the centrality of both children’s autonomy and supportive prosocial expectations in how children’s helpfulness is supported in this and similar cultural communities. By contrast, middle-class European American mothers frequently responded to questions about their child’s efforts to help with linguistic forms that “pivoted” to either the mother as the focal agent in the child’s prosocial engagement or to reframing the child’s involvement to emphasize non-help activities. Correspondence between cultural differences in the linguistic findings and existing literature on socialization of children’s prosocial helping is discussed. Also discussed is the analytic approach of the study, uncommon in developmental psychology research, and the significance of the linguistic findings for understanding parental ethnotheories in each community. (shrink)

Interface theory is the hypothesis that inferential, representational theories of perception entail that fitness, not truth, dictates the evolution of perceptual systems. They show, with simulations, that “veridical” perceptual mappings (ones that preserve at least some of the structure of the world) are routinely out-competed by “non-veridical” interfaces (ones that make no attempt to preserve that structure). They therefore take particular aim at the direct perception, ecological approach to perception and work to show that such a system, even if technically (...) an option, would never be selected for by evolution. This paper defends the ecological approach from this novel, existential attack by showing that the ecological hypothesis is so different in kind to the inferential, representational view of perception that it simply falls outside the scope of interface theory’s critiques; ecological psychology remains a viable scientific endeavor. This analysis will show that, far from being a radical new approach to perception, interface theory is simply a clear and elegant formalization of mainstream representational psychology, and any implications interface theory may have belong solely to that branch of science. (shrink)

Recent literature on epistemic innocence develops the idea that a defective cognitive process may nevertheless merit special consideration insofar as it confers an epistemic benefit that would not otherwise be available. For example, confabulation may be epistemically innocent when it makes a subject more likely to form future true beliefs or helps her maintain a coherent self-concept. I consider the role of confabulation in typical cases of interpersonal gaslighting, and argue that confabulation will not be epistemically innocent in such cases (...) even if it does preserve a coherent self-concept or belief-set for the subject. Analyzing the role of confabulation in gaslighting illustrates its role in on-going interpersonal relationships, and augments already growing evidence that confabulation may be quite widespread. The role of confabulation in gaslighting shows that whether confabulation confers epistemic benefits will depend greatly on the interpersonal context in which it is deployed, while whether a coherent self-concept is epistemically beneficial will depend to a great extent on the content of that self-concept. This shows that the notion of an epistemically harmful or beneficial feature of a cognitive process can and should be further clarified, and that doing so has both theoretical and practical advantages in understanding epistemic innocence itself. (shrink)

Purpose This paper aims to analyze some of the epistemically pernicious effects of the use of the internet and social media. In light of this analysis, it introduces the concept of epistemic pornography and argues that epistemic agents both can and should avoid consuming and sharing epistemic pornography. Design/methodology/approach The paper draws on research on epistemic virtue, cognitive biases, social media use and its epistemic consequences, fake news, paternalistic nudging, pornography, moral philosophy, moral elevation and moral exemplar theory to analyze (...) the epistemically pernicious effects of the internet and social media. Findings There is a growing consensus that the internet and social media activate and enable human cognitive biases leading to what are here called “failures of epistemic virtue.” Common formulations of this problem involve the concept of “fake news,” and strategies for responding to the problem often have much in common with paternalistic “nudging.” While fake news is a problem and the nudging approach holds out promise, the paper concludes that both place insufficient emphasis on the agency and responsibility of users on the internet and social media, and that nudging represents a necessary but not sufficient response. Originality/value The essay offers the concept of epistemic pornography as a concept distinct from but related to “fake news” – distinct precisely because it places greater emphasis on personal agency and responsibility, and following recent literature on moral elevation and moral exemplars, as a heuristic that agents might use to economize their efforts at resisting irrational cognitive biases and attempting to live up to their epistemic duties. (shrink)

In the Grundlagen , Frege offers eight main arguments, together with a series of more minor supporting arguments, against Mill’s view that numbers are “properties of external things”. This paper reviews all eight of these arguments, arguing that none are conclusive.

An argument whose conclusion C is essential evidence for one of its premises can provide its target audience with justification for believing C. This is possible because we can enhance our justification for believing a proposition C by integrating it into an explanatory network of beliefs for which C itself provides essential evidence. I argue for this in light of relevant features of doxastic circularity, epistemic circularity, and explanatory inferences. Finally, I confirm my argument with an example and respond to (...) objections. (shrink)

Genetic variation in fitness is the fundamental prerequisite for adaptive evolutionary change. If there is no variation in survival and reproduction or if this variation has no genetic basis, then the composition of a population will not evolve over time. Consequently, the factors influencing genetic variation in fitness have received close attention from evolutionary biologists. One key factor is the mode of reproduction. Indeed, it has long been thought that sex enhances fitness variation and that this explains the ubiquity of (...) sexual reproduction among eukaryotes. Nevertheless, theoretical studies have demonstrated that sex need not always increase genetic variation in fitness. In particular, if fitness interactions among beneficial alleles (epistasis) are positive, sex can reduce genetic variance in fitness. Empirical data have been sorely needed to settle the issue of whether sex does enhance fitness variation. A recent flurry of studies1-4 has demonstrated that sex and recombination do dramatically increase genetic variation in fitness and consequently the rate of adaptive evolution. Interpreted in light of evolutionary theory, these studies rule out positive in these experiments epistasis as a major source of genetic associations. Further studies are needed, however, to tease apart other possible sources. BioEssays 25:533–537, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

There are broad commonalities between the projects of Donald MacKinnon (1913–1994) and Stanley Cavell (1926–) sufficient to make the claim that they struck an analogous pose in their respective contexts. This is not to discount their manifest differences. In the milieu of 1960s and 1970s Cambridge, MacKinnon argued in support of a qualified language of metaphysics in the service of a renewed catholic humanism and Christian socialism. At Harvard, Cavell articulated commitments that made him more at home in the world (...) of North American secular political liberalism. Where Nietzsche, Hume, Freud, Heidegger, Emerson and Thoreau were Cavell’s inspirations, Butler, Kant, G. E. Moore, Collingwood and the New Testament were MacKinnon’s. For all the stark differences, commonalities abound and the reason for this can be traced to a shared appreciation of Austin’s contribution to the ‘lingusitic turn’ together with Wittgenstein’s later work. They both developed projects obsessed with the problem of scepticism together with a commitment to a creative re-animation of moral discourse in light of it, with MacKinnon defending a qualified ‘moral realism’, and Cavell, ‘moral perfectionism’. Seen together, a distinctive post-Kantian and post-Wittgensteinian therapeutic moral philosophy is in evidence. (shrink)

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Progress in emergency and critical care requires that clinical research be performed on patients who are incapable of granting consent for research participation. Analyses of the ethics of such research have left some questions incompletely answered. Why should we be permitted to expose vulnerable patients to research risks without their consent? In particular, how do we justify research interventions that have no potential benefit for participants (nontherapeutic interventions)? This article presents a moral justification for nontherapeutic interventions in emergency research. By (...) relying on a framework for assessing research risks, and by drawing on the example of pediatric research, this justification is founded in how institutional review boards, and society in general, analyze risk. Our justification for emergency research also suggests additional protections for emergency research participants, including a stringent threshold for research risk, that still permit important research to proceed. (shrink)